Our research on phenomenology has focused on determining: 1) whether negative symptoms are best conceptualized as a categorical, dimensional, or hybrid construct; 2) how many domains are part of the negative symptom construct. Our findings indicate that negative symptoms are a hybrid dimensional-categorical construct, such that people with schizophrenia differ in kind above a certain symptom threshold that is predictive of individual differences in the severity of several external correlates. Early work that we and others conducted on the factor structure of negative symptoms supported a two dimensional conceptualization. However, most recently, we have found that the construct is best considered in relation to 5 domains (anhedonia, avolition, asociality, blunted affect, alogia); this finding has been replicated using multiple mathematical techniques (e.g., CFA and network analysis), using multiple scales (BNSS, CAINS, SANS), and across multiple cultures, suggesting that the 5 domain conceptualization is robust. Recently, we have been examining whether these 5 domains have distinct pathophysiological mechanisms and clinical correlates to determine whether a change is needed for DSM-5 negative symptom diagnostic criteria and whether the 5 domains reflect distinct treatment targets.
The development of next-generation negative symptom assessments has been another key focus of research in the CAN Lab. In 2005, NIMH held a consensus development conference on negative symptoms. A key conclusion of this meeting was that new rating scales were needed to increase chances of observing treatment effects. Two second generation negative symptom rating scales resulted from this initiative. Dr. Strauss was co-developer of one of these scales, the Brief Negative Symptom Scale (BNSS), and served as PI on multiple studies validating the scale. Dr Strauss has also led efforts in translating the BNSS into over a dozen languages and facilitating its primary intended use as an outcome measure in industry sponsored clinical trials. Most recently, he co-developed and validated a new scale for those at high-risk, the Prodromal Inventory for Negative Symptoms, which is being examined in an R01 from NIMH. He has also begun developing and validating novel digital phenotyping measures of negative symptoms that likely reflect the third generation of negative symptom assessment (e.g., geolocation, accelerometry, ambient sound, measures of facial and vocal affect recorded from ambulatory videos). We are pioneering novel "big data" analytic approaches to analyzing these novel mobile technology based negative symptom assessments and working to develop a standardized app and norms for the general population and individuals with schizophrenia.
The primary focus of our research is on identifying mechanisms underlying negative symptoms. Our initial studies examined the most straightforward explanation for avolitional symptoms in schizophrenia- that patients fail to engage in activities because they do not find them rewarding; however, this hypothesis was not supported because subjective and neurophysiological response to rewarding stimuli is intact in schizophrenia. This finding lead us to explore why apparently normal hedonic responses do not translate into goal-directed behavior in schizophrenia. We have demonstrated that abnormalities in several aspects of reward processing (e.g., reinforcement learning, effort-cost computation, value representation, uncertainty-driven exploration) that are driven by aberrant cortico-striatal interactions may prevent intact hedonic responses from influencing decision-making processes that are needed to initiate motivated behavior. We have also demonstrated that avolition is associated with dysfunctional cognition-emotion interactions (e.g., memory, attention), emotion regulation abnormalities, social cognition impairments, a reduction in the positivity offset, and anhedonic beliefs. Most recently, we have expanded our work on the etiology of negative symptoms into the psychosis prodrome, where we have found that reward processing deficits predict the severity of negative symptoms in at-risk youth. However, due to the greater propensity for depression in this phase of illness, hedonic deficits play a greater role in negative symptoms in the prodrome than in schizophrenia, propagating forward and creating deficits in other aspects of reward processing that also occur in schizophrenia. We are currently conducting longitudinal studies to determine which reward processing mechanisms associated with negative symptoms predict the emergence of psychotic disorders versus other conditions (e.g., depression) in youth at clinical high-risk for psychosis.
In collaboration with colleagues in psychiatry, I have conducted clinical trials examining the efficacy of pharmacological treatments for negative symptoms. Based on our studies showing a role for endogenous oxytocin in social cognition deficits and negative symptoms, we examined the efficacy of oxytocin as a treatment for asociality. In two trials, oxytocin was not more effective than placebo, and we recently extended this work by demonstrating that combining oxytocin with psychosocial treatment has no added benefit over psychosocial treatment alone. Most recently, we are exploring the efficacy of a novel app-based cognitive training intervention for improving emotion regulation abnormalities via a direct mechanistic effect on the prefrontal cortex. We are examining whether increased prefrontal activation leads to better emotion regulation, and whether this translates into reductions in negative symptoms, positive symptoms, and improved functional outcome.
We use EEG to examine the time-course of neural activity in relation to various emotional and cognitive processes. EEG involves recording electrical activity along the scalp. EEG measures voltage fluctuations resulting from ionic current flows within neurons. In our studies, we have primarily been interested in Event Related Potentials (ERPs), which are averaged EEG responses that are time-locked to stimuli in an experiment. For example, we have examined time-locked response to pleasant, unpleasant, and neutral images to explore the time-course of affective response in people with schizophrenia compared to controls. Our EEG studies are conducted within our laboratory in the Psychology Department. We have two 64-channel Brain Vision ActiChamp Systems. We have been using EEG/ERPs since 2010.
We use eye-tracking to measure the role of visual attention in various cognitive and emotional processes. We do this by measuring point of gaze or motion of the eyes relative to the head and a stimulus presented on the computer screen using an eye-tracker. The eye-tracker monitors the position of the pupil, pupil size, and corneal reflection as a participant views images on the screen. We have used eye-tracking to explore individual components of attention and how they interact with emotional vs. neutral stimuli in people with schizophrenia and controls. We are also interested in how pupil dilation is impacted by various manipulations of emotion and cognitive load. Our lab has two SR Research Eyelink 1000 systems that are used to measure attentional allocation and pupil dilation. This desktop mounted system allows for a remote and headfree evaluation of eye-movements at a very high sampling rate. We also interface EEG/ERPs and eye-tracking in the lab and fMRI and eye tracking at the BIRC. We have been using eye tracking since 2004.
Our fMRI studies are conducted at UGA's Biomedical Imaging Research Center (BIRC): https://birc.uga.edu/. The BIRC houses a state-of-the-art, General Electric 16-channel fixed-site Signa HDx 3.0 Tesla Magnetic Resonance Imaging (MRI) magnet. The magnet makes available multiple magnetic resonance imaging techniques including magnetic resonance imaging for structural tissue imaging (MRI), functional neuroimaging (fMRI) for studies of brain activation in real time, magnetic resonance spectroscopy (MRS) for the study of chemical changes in the brain, and magnetic resonance angiography (MRA) for the study of vascular changes throughout the system. Multinuclear spectroscopy (MNS) is available for enhanced spectroscopic studies and includes phosphorous-31. We have been using fMRI since 2019.
We use the wireless Bionomadix recording system from Biopac to examine facial electromyography, respiration, heart rate, and skin conductance. These psychophysiological measures allow us to explore the timecourse of psychophysiological response in relation to emotional reactivity and emotion regulation tasks, as well as the coherence between subjective, neural, and peripheral psychophysiological response when used in conjunction with our other measures. We use the wireless bionomadix system in our studies involving social interaction, as well as more traditional computerized laboratory paradigms examining emotion. We have been using peripheral psychophysiology since 2013.
We use digital phenotyping to explore symptoms and their mechanisms as they occur in everyday life. Participants are asked to carry a smart phone and wear a digital band that collects psychophysiology for several days in the context of everyday life. Participants report their current activities, as well as their emotional experience during those activities at several points throughout the day. The internal sensors of the phone also passively collect objective data related to behavior via measurements of accelerometry, geolocation, and ambient sound. Participants also record brief videos on the cell phone that are later submitted to automated algorithms for processing facial and vocal affect. We are using these digital phenotyping methods to explore hypotheses related to negative symptoms, as well as the reliability and validity of active and passive data collection methods as third-generation negative symptom measures. We have been using digital phenotyping since 2015.
We obtain salivary and blood samples to test hypotheses related to neuroendocrine (e.g., cortisol) and immune (cytokines) function in relation to task performance. Salivary samples are obtained and stored in a -40 freezer located in our lab in the Psychology building. Blood samples are obtained and stored at the Clinical Translational Research Unit on the UGA Medical School campus. We have been gathering saliva/blood draws since 2010.
1. R01-MH120092 (PI: GP Strauss) 04/01/2020-03/31/2025
4/5 CAPER: Computerized Assessment of Psychosis Risk
This grant develops and validates a novel computerized screening battery for the early identification of psychosis among youth with prodromal syndromes.
2. R61-MH121560 (PI GP Strauss) 04/01/2020 – 03/31/2025
Cognitive training for emotion regulation in psychotic disorders.
This grant examines the efficacy of a novel app-based cognitive training program for enhancing the proximal target of emotion regulation via a direct mechanistic effect on increasing prefrontal activation, as well as a distal target of improving symptoms and functional outcome.
3. R21-MH119438 (PI GP Strauss) 09/01/2019-08/31/2021
Mechanisms Underlying Emotion Regulation Abnormalities in Youth at Clinical High-Risk for Psychosis
This grant examines mechanisms underlying emotion regulation abnormalities at the identification, selection, and implementation stages in youth at clinical high-risk for psychosis using EMA, ambulatory psychophysiology, EEG, pupillometry, and eye-tracking.
4. R01-MH116039 (PI GP Strauss) 03/01/2019-11/30/2023
Prodromal Inventory for Negative Symptoms (PINS): A Development and Validation Study
This grant develops and validates novel methods for assessing negative symptoms in youth at clinical high-risk for psychosis to enhance risk prediction algorithms
5. R21- MH112925 (PI GP Strauss) 04/01/2017- 03/31/2020
Modeling anhedonia in schizophrenia: A stochastic dynamical systems approach
This grant applies mathematical models to ecological momentary assessment data to test novel theories about anhedonia reflecting abnormalities in the temporal dynamics of emotion in schizophrenia.
6. NARSAD Young Investigator Grant (PI GP Strauss) 01/15/2019-01/15/2021
Brain & Behavior Research Foundation $70,000
Neurocomputational models of psychosis risk
This grant uses computational modeling approaches to examine mechanisms underlying positive and negative symptoms involved with conversion to a psychotic disorder in youth at clinical high-risk for psychosis.
7. University of Georgia (PI GP Strauss) 8/1/2019-5/30/2020
Clinical Translational Research Unit Pilot Grant $40,000
Mechanisms of amotivation in youth at clinical high-risk for psychosis
This grant uses fMRI to examine neural circuitry involved with reward processing mechanisms underlying avolition in youth at clinical high-risk for psychosis.
1. R21 –MH122863 (PI: GP Strauss) 04/01/2020-03/31/2022
Computationally modeling the failure of effort to become a secondary reinforcer in schizophrenia
This grant uses computational modeling and pupillometry to test the novel hypothesis that avolition in schizophrenia results from a failure of effort to become a secondary reinforcer
Score: Priority score = 24; 5th percentile
1. University of Georgia (PI GP Strauss) 10/15/2017-6/30/2019
Clinical Translational Research Unit Pilot Grant $25,200
The Effects of Inflammation on Neurocomputationally Derived Reinforcement Learning Profiles in Schizophrenia
This grant examines whether cytokines predict computationally derived measures of reinforcement learning in schizophrenia to index the contributions of inflammation to negative symptoms.
2. University of Georgia (PI GP Strauss) 11/01/2017-06/30/2017
Owens Institute for Behavioral Research Pilot Grant $10,000
Neurocomputational Models of Reinforcement Learning in Youth at Clinical High-Risk for Psychosis
The study examines a computational neuroscience framework for understanding delusions and avolition in youth at clinical high-risk for psychosis using computational models of reinforcement learning.
3. NSF Graduate Research Fellowship (PI: KH Frost) 08/31/2015-08/30/2018
National Science Foundation $105,600
The Effects of Acute Social Stress on Reward Processing in Humans
This mentored grant examines sex differences in the effects of acute social stress on reward processing in humans, including implicit reinforcement learning, prediction error signaling, value representation, reward anticipation, reward consummation, effort-cost computation, and action selection.
4. R34-MH100362 (PI: RW Buchanan) 3/31/13 – 3/31/2016
Combined Oxytocin and CBSST for Social Function in People with Schizophrenia
The study examines the efficacy of oxytocin combined with cognitive behavior therapy social skills training (CBSST) at improving social outcome in people with schizophrenia.
5. Wechsler Early Career Grant for Innovative Work in Cognition 10/01/2015-2/30/2017
American Psychological Foundation (APF) $25,000
A Cognitive Neuroscience Account of Low Cognitive Effort in Schizophrenia
This grant explores a novel account of low effort in schizophrenia as resulting from failure to detect cognitive demands and adjust effort levels accordingly to maximize cognitive performance.
6. Interdisciplinary Collaborative Grant (PI: GP Strauss) 05/01/2015 – 12/30/2016
State University of New York $10,000
Using Network Analysis to Explore the Temporal Dynamics of Emotion in Schizophrenia.
This study uses network analysis to Ecological Momentary Assessment data in people with schizophrenia to determine whether anhedonia reflects abnormal temporal dynamics of emotional experience.
7. Transdisciplinary Areas of Excellence Grant (PI: GP Strauss) 05/01/2015-12/30/2016
State University of New York $20,000
Predicting Conversion to Psychosis in At-Risk Youth: The Role of Stress-Inflammation Interactions.
The study examines whether biomarkers of stress and inflammation following an acute social stressor predict symptoms of attenuated psychosis and conversion to a psychotic disorder in at-risk youth.
8. K23-MH092530 (PI: GP Strauss) 09/08/10 – 09/30/2015
Motivated Attention and Avolition in Individuals with Schizophrenia
The study examines early emotion processing abnormalities in schizophrenia, and attempts to identify precise cognitive mechanisms that contribute to abnormal attention-emotion interactions in schizophrenia. Career development activities include training in Event Related Potential and Eye-Tracking technology, as well as the theoretical basis of cognitive/affective neuroscience.
9. Department of Veterans Affairs (PI: GP Strauss) 10/01/2011 –09/30/2013
MIRECC VISN 5 $50,000
Oxytocin and Social Cognition in Schizophrenia
The study examined the role of the oxytocin receptor gene and plasma oxytocin levels in deficits in social cognition, emotional experience, emotion perception, and emotional memory in people with schizophrenia.
10. Department of Veterans Affairs (PI: GP Strauss) 10/01/2012 –09/30/2013
MIRECC VISN 5 $25,000
A Study of Subjective Emotional Experience and Emotion Regulation in Schizophrenia using an Experience Sampling Approach
The study used experience sampling methodology to examine differences in prospective, retrospective, and in-the-moment reports of positive and negative emotion in people with schizophrenia and healthy controls, as well as the effectiveness of various emotion regulation strategies in the context of every-day life.
11. Department of Veterans Affairs (PI: GP Strauss) 10/01/2010 –09/30/2011
MIRECC VISN 5 $25,000
Cognitive Behavioral Social Skills Training to Enhance Consumer Recovery in
The study examined the efficacy of Cognitive Behavioral Social Skills Therapy enhanced with new techniques that foster optimism, hope, mastery, empowerment, and self-esteem for consumer-oriented recovery in schizophrenia.
12. T32-MH067533 (PI : WT Carpenter) 07/01/2010-06/30/2015
Multidisciplinary Schizophrenia Research Training
The major goals of the project are to provide young investigators with research training in
schizophrenia research to facilitate their goals of becoming an independent investigator.
13. P50-MH082999 (PI: WT Carpenter) 09/01/08- 08/31/12
MPRC Centers for Intervention Development and Applied Research (CIDAR)
This application proposes to establish a Center for Intervention Development and Applied Research (CIDAR) in response to PAR-05-039. Its focus will be to advance drug discovery using innovative evaluation platforms and testing drugs with novel molecular targets to address negative symptoms and cognitive impairments in schizophrenia.
The BNSS is a 13-item psychiatric rating scale designed to assess the negative symptoms of schizophrenia. The scale is rated after completing a 15-minute interview. The BNSS includes a brief but comprehensive 9 page manual, a workbook to be used when conducting the clinical interview, and a scoresheet. In multiple psychometric studies, the BNSS has demonstrated excellent inter-rater agreement, internal-consistency, test-retest reliability, convergent validity, and discriminant validity. It produces a 5 factor solution for the domains of anhedonia, avolition, asocality, restricted affect, alogia. The BNSS has been, or is currently in the process of being translated into several languages, including: Spanish, Italian, German, Cantonese, French, Korean, and Turkish. Individuals interested in obtaining BNSS materials and publications can visit our Resources page. Commercial entities wishing to use the BNSS in clinical trials can contact Prophase, which offers professional BNSS training that was developed in consultation with the test developers. Drs. Strauss and Kirkpatrick receive royalties and consultation fees from Prophase LLC in connection with commercial use of the BNSS and other professional activities. Individual researchers/research groups may use the BNSS free of charge and obtain training materials by contacting Dr. Strauss firstname.lastname@example.org or Dr. Kirkpatrick email@example.com
The PINS is a new measure being developed via a multi-site collaborative R01 from NIMH as part of the Georgia and Illinois Negative Symptom Study (GAINS). The study is conducted in the laboratories of Dr. Gregory Strauss at UGA, Dr. Vijay Mittal at Northwestern, and Dr. Elaine Walker at Emory University. It is a clinical rating scale designed to assess negative symptoms in the prodromal phase of illness specifically. The measure is currently undergoing revision as part of an iterative data-driven process intended to produce a finalized briefer scale. To obtain the latest version please email Dr. Strauss firstname.lastname@example.org or Dr. Mittal: email@example.com
We are developing and validating a number of novel digital phenotyping methods for assessing psychiatric symptoms. These involve active methods (e.g., daily surveys, cognitive tests, videos) completed by the participant on the phone, as well as passive methods that involve unobtrusively recording objective emasures of symptoms via the internal sensors of the phone (e.g., geolocation, accelerometry, ambient sound). Contact Dr. Strauss at firstname.lastname@example.org for details.